My experience with Ledderhose disease aka plantar fibromatosis. This information is not intended to replace your doctor. Information on this blog is provided for informational purposes only. You should not use the information on this web site for diagnosing or treating.
Today I got an e-mail telling me that there was a new paper out relating to Dupuytren's (thank you Google Alerts), so I went and had a look and it is another paper that is looking at collagenases such as Xiapex/Xiaflex. For those who don't know these are enzymes that break down the main complex that forms the cords in Dupuytren's and I have heard that it does have some positive influence on nodules as well.
For background information see some of my previous posts which include:
Well the typical follow up period in the trials was 3 months and here they go up to a year in what is unfortunately a small sample group of only 12 patients and they find that: (Just because I like at least one picture per blog post):
Although the majority of the patients are fine 2 do have side effects, in the pie chart this may look like a small amount but imagine this applied to 1200 people rather than 12 and suddenly that is 200 people with problems.
These two patients had significant disability in the injected hand and also suffered from pain and in both case operative intervention was taken a year after the treatment with the collagenase. They found that there was deep tissue scarring that was presumably caused by the injection and that this could be the cause of finger stiffness and pain. They then waffle on about science stuff and come to the conclusion that long term problems is something that those administering this drug should consider both before and after giving the treatment.
If you are interested in learning more about this then please e-mail me, post a comment or hop over to the forum and share your story at the same time.