This page may be of interest for Dupuytren's patients: http://www.plasticsurgerysf.com/scrapbook/
I have treated thousands of patients with Dupuytren contracture and have seen hundreds with Ledderhose.
For Ledderhose, I occasionally have excised, wide-awake, but scar tissue tends to replace the Ledderhose. I have done this in about half-dozen patients.
These are chronic conditions and are managed, not cured.
Keep the treatments simple with needle, or enzyme, or both. Save surgery (has highest complication rate) for severe cases not amenable to the other treatments.